Let’s start by having insight into how these callus remover gels work… the best callus remover gels have strong, active ingredients such as salicylic Acid and Potassium Hydroxide to name a few. Salicylic Acid and Potassium Hydroxide are significantly strong acids which mean that the remover gel works effectively to remove the calluses in a matter of few minutes, making your calluses soft and easy to peel off with callus remover gels. When applying, check the appropriate application duration specified on the back of the package. If not specified, the ideal time to leave the callus remover gel work on your callus is normally 3-5 minutes. Read the instruction on the package thoroughly, so that you get to know the requirement before applying the gel/lotion.